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KMID : 0604520230490030285
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Journal of the Society of Cosmetic Scientists of Korea
2023 Volume.49 No. 3 p.285 ~ p.290
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Anti-inflammatory Effects of Lactobacillus johnsonii Lysate via Regulation of NF-κB Activity
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Cha Hwa-Jun
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Abstract
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In this study, the anti-inflammation efficacy of Lactobacillus johnsonii derived from Kimchi was investigated.
Raw 264.7 cells, which are rat-derived macrophages, were treated with Lactobacillus johnsonii lysate to confirm the expression level of TNFα and IL1β, which are inflammatory markers, and when treating 250 μg/mL extract, the exp ression level of TNFα and IL1β decreased by 40.55% and 34.66% compared to the control group treated with 1 μg/mL LP, respectively. In addition, as a result of confirming the transcriptional activity of NF-κB, a key transcription factor in cytokine expression by LPS, it was confirmed that the transcriptional activity of NF-κB was 40.76% inhibited compared to the control group treated with 1 μg/mL LPS. Therefore, the results of this study confirmed that Lactobacillus johnsonii lysate is likely to be an anti-inflammatory or skin-soothing functional material by preventing the expression of cytokine by LPS and controlling NF-κB transcriptional activity.
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KEYWORD
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Lactobacillus johnsonii, NF-κB, inflammation, skin calming
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